Safer Design for Nanomaterials

SaferNanoDesign

How can industrial innovation in nanotechnologies be reconciled with the legitimate concerns of citizens regarding environmental protection and public health? SaferNanoDesign will familiarize early-stage researchers and postgraduate students (2nd year Master/PhD) with risk evaluation using computational methods of modeling and simulation relevant to nanomaterials.

Summary

SaferNanoDesign’s mission is to tackle the challenges of safer eco-design for Nanomaterials of. To do so, the School is centered on the reorientation of toxicity testing towards evaluation of the responses of toxicity pathways, i.e. perturbing normal cellular signaling pathways by exposure to nanomaterials in well-designed in vitro assays using human cells. This new paradigm would replace the current approach of relying almost exclusively on high-dose phenotypic responses in animals. An intensive one-week specialist school, Safer NanoDesign examines the analytical tools and methodologies required to rise to the challenge of the ecodesign of nanomaterial-enabled technology. The School will use a dynamic approach, involving complex problem solving, with a case study on the next generation monitors incorporating both Quantum-Dot LED display with silver nanowire..

SaferNanoDesign combines an intensive program of lecture presentations followed up by practical sessions  (experiments, computer simulation and modeling) and interdisciplinary group work. Courses will be given by international experts from France, Scotland, the US, the Netherlands and Switzerland and representatives from industry and regulatory bodies. The working language of the school is English. SaferNanoDesign will be held from June 12th to 18th, 2016 at ESI in Archamps Technopole (France), 15 minutes from Geneva.

Programme

SaferNanoDesign is an interdisciplinary course addressing:

  • 1st Session: Nanomaterials and their life-cycle analysis.

The design of nanomaterials in the context of materials science and market reality.

  • 2nd Session: Nanomaterials transformation in the environment; Ecosystem and Human Exposure.

The interaction of nanomaterials with their physical, chemical and biological environment and the corresponding impact on product life-cycle.

  • 3rd Session: Toxicology and Risk assessment

The evaluation of potential risks related to exposure and toxicity, the regulatory and ethical considerations and the roles of bodies such as the EU, the ILO, the OECD.

  • 4th Session: Technology transfer and Business development.

The challenges and opportunities of marketing nano-based products for an SME, including  a mastery of the general legislation concerning eco-design at EU and national levels, as well as working knowledge of value chain issues. It also includes the capacity to analyze in specific contexts how innovative strategies may lead to improved firm performance or to new business perspectives.

Download the draft programme (currently being updated).

Learning Outcome

At the end of SaferNanoDesign, students will have gained:

  • An in-depth insight into the design of nanomaterials with specific and innovative industrial applications but safe for humans and the environment.
  • Practical experience of exposure assessment and the development of predictive risk analysis based on modeling of the life cycle, from the production to the end of life, of nano enabled products in the environment.
  • Theoretical and practical understanding of nanomaterial reactivity and transformation in the environment.
  • Knowledge of the different types of assays available to assess the impact of nanomaterial exposure at different levels (environment, organism, cell, molecule etc.).
  • Knowledge of how to obtain and analyze « omics » data to perform gene ontology and pathway analysis. They will also become familiar with predictive toxicology via the adverse outcome pathways (AOP) and Effectopedia tool.
  • An understanding of the challenges and opportunities of marketing nano-based products for an SME.
  • The capacity to analyze in specific contexts how innovative strategies may lead to improved industrial performance and new business perspectives
Examination and credits rewarded

3 ECTS are awarded to Master and PhD students after taking part in the Oral defense (Pitch session), and after submitting the individual assignment (deliverables) no later than two weeks after the Summer School. The ECTS are delivered by Université Grenoble Alpes in an official letter of participation and transferred to the partner universities.

Scholarships

Up to twenty scholarships are available from COST-Modena and Partner Institutions to the best ranked students. These awards cover accommodation and travel expenses.

Deadline for applications

March 1- May 12, 2017

Location and dates

European Scientific Institute, Archamps Technopole, France (15 minutes from Geneva airport).
June 14- 20, 2017

Partner Institutions

SaferNanoDesign is jointly organised by Université de Grenoble Alpes and Aix-Marseille Université. SaferNanoDesign is supported by the SERENADE Labex, the bioHealth Computing consortium, and COST-Modena European Programme. SERENADE, which is coordinated by CEREGE and funded by the French National Research Agency (ANR «Investissements d’Avenir»), associates French Universities (Aix-Marseilles, Grenoble Alpes, Paris Est, and Novancia School of Management), CNRS (CEREGE, LCE, IMBE, LEMIRE and ISTerre), CEA (Cadarache, Marcoule, Grenoble), INSERM (Paris), INRA (Nantes, Toulouse, Montpellier), INERIS and industries (ARKEMA, ALLIOS, SUEZ-ENVIRONNEMENT, CALCIA, DANONE, AFIPEC, UIC). SERENADE has développed international partnerships with US CEINT (Consortium for Environnemental Implications of Nanotechnology, which is coordinated by DUKE University), Berkley labEPFL Lausanne, EAWAG Zurich, and Universities of Wien, Manchester, New South Wales (UNSW, Australia).

serenade

Scholarships are proposed by the LabEx SERENADE funded by the French National Research Agency (ANR «Investissements d’Avenir»).


cost

Modena

Scholarships are also proposed by MODENA, which is a COST- supported action promoting and to co-ordinating inter-disciplinary collaborations, with the ultimate aim of producing Quantitative Nanostructure-Toxicity Relationships (QNTR) models …